Argos Therapeutics has announced the presentation of positive interim data from a Phase 2 trial that evaluated the clinical activity, safety and immune response of AGS-003 treatment, given in combination with sunitinib, in patients with newly diagnosed advanced renal cell carcinoma (RCC). AGS-003 is a product of the Company’s Arcelis™ technology, and is a personalized, RNA-loaded, dendritic cell-based immunotherapy that is individualized to each patient’s unique tumor.

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According to new scientific findings published in Cancer Research, a journal of the American Association for Cancer Research, immune responses has the ability to kill tumors before they can be directed toward normal body tissue. Lead researcher Richard G. Vile, Ph.D said, “There are extremely precise mechanistic methods augmenting the ability of the immune system to distinguish between normal tissues and tumors.” “Understanding the multiple checks and safeguards against autoimmunity should allow us to understand more closely how to generate antitumor immunity,” she added.